UPS aircraft explodes throughout takeoff at Kentucky airport, leaving large plume of smoke and a number of injured

A massive UPS plane exploded as it took off from Kentucky Tuesday evening, leaving multiple people injured and sending a massive plume of smoke spreading across the city.

Video shared to social media showed a ball of fire emanating from the center of the plane just moments after it departed the runway. 

Louisville Metro Police have since announced on social media that several agencies are responding to the scene south of Louisville Muhammad Ali International Airport, as smoke filled the sky from the area.

Details about the collision remain unclear, but a source with knowledge of the situation told CNN it involved a UPS MD-11 plane.

A MetroSafe supervisor told WDRB the incident began with calls about an explosion, and Metro Police spokesman Matt Sanders said the department received 20 calls for service. 

Authorities said it remains an active scene with ‘smoke and debris,’ as they issued a shelter-in-place order for a five mile radius around the airport. 

‘Please remain away from the area until further notice,’ the police department urged. 

Multiple people were injured when a plane crashed near a Kentucky airport on Tuesday, sending a massive plume of smoke across the city

Authorities have issued a shelter-in-place order for a five mile radius around the airport

 This is a breaking news story and will be updated.